Flavanol Absorption, Metabolism and Excretion From Fruit-based Drinks and Other Food Matrixes

Summary

Dietary intervention study in healthy adult males to evaluate concentration of flavanol metabolites in plasma and urine after single acute intakes of flavanols from different fruit-based drinks.

Conditions

• Healthy

Interventions

OTHER

Flavanols-capsules

Capsules containing 456 mg cocoa flavanols and 315 g of milk (1% fat)

OTHER

Flavanol-banana blend

Fruit blend prepared by mixing 177 g ripe, frozen bananas, 240 g almond milk and a chocolate flavored powder containing 626 mg cocoa flavanols

OTHER

Flavanol-high protein drink

Drink prepared by mixing 225 mL of a chocolate flavored high protein dairy drink with a CF powder containing 533 mg cocoa flavanols

OTHER

Flavanol-berry blend

Flavanol-berry blend prepared by mixing 120 g almond milk, 70 g water, 95 g yogurt, 50 g each strawberries, blueberries, blackberries, raspberries, 105 g crushed ice and a fruit-flavored powder containing 561 mg cocoa flavanols

OTHER

Flavanol-sports drink

Drink prepared by mixing 488 g of a sports drink with a CF powder containing 533 mg cocoa flavanols

OTHER

Flavanol-peanut butter toast

Prepared by mixing 32 g peanut butter with a chocolate flavored powder containing 602 mg cocoa flavanols and spread on 1 slice toasted bread (50 g) and 50 g sliced strawberries

OTHER

Flavanol-oats

Prepared by mixing 40 g quick oats with 237 g boiling water and combined with a chocolate flavored powder containing 602 mg cocoa flavanols

OTHER

Flavanol-yogurt

Prepared by 227 g yogurt (0% fat) mixed with a fruit-flavored powder containing 561 mg cocoa flavanols

OTHER

II- Flavanol drink

Drink prepared by mixing 240 g almond milk with a chocolate flavored powder containing 626 mg cocoa flavanols

OTHER

II- Flavanol drink + banana blend

Drink 1 (Flavanol drink): prepared by mixing 120 g almond milk with 626 mg cocoa flavanols Drink 2 (Fruit blend): prepared by mixing 120 g almond milk blended with 177 g ripe, frozen bananas

Sponsors & Collaborators

• Mars, Inc.

  collaborator INDUSTRY

• University of California, Davis

  lead OTHER

Principal Investigators

• Carl L Keen, PhD · UC Davis

• Javier I Ottaviani, PhD · Mars, Inc.

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

25 Years

Max Age

60 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-05-05

Primary Completion

2018-02-09

Completion

2018-02-09

Countries

• United States

Study Locations