Flavonoids, Blood Pressure and Blood Vessel Function

Summary

The primary aim of this placebo-controlled study is to determine whether flavonoids beneficially affect markers of cardiovascular disease risk in healthy subjects at elevated cardiovascular risk.

The underlying mechanisms of action of flavonoids will be assessed on blood biomarkers and we will assess the effects of the food matrix, and aspects of isoflavone metabolism.

Conditions

• Cardiovascular Disease Risk Reduction

Interventions

DIETARY_SUPPLEMENT

Flavanone - supplement

acute single optimal dose

OTHER

Flavanone - food

acute single dose

OTHER

Flavanone - placebo

acute single dose (flavanone free)

DIETARY_SUPPLEMENT

Isoflavone - supplement

acute single optimal dose

OTHER

Isoflavone - food

acute single optimal dose

OTHER

Isoflavone - placebo

acute single dose (isoflavone free)

DIETARY_SUPPLEMENT

Isoflavone - metabolite supplement

acute single optimal dose of commercial product

DIETARY_SUPPLEMENT

Flavan-3-ol - supplement

acute single optimal dose

OTHER

Flavan-3-ol - food

acute single optimal dose

OTHER

Flavan-3-ol - placebo

acute single dose (flavan-3-ol free)

DIETARY_SUPPLEMENT

Anthocyanin - supplement

acute single optimal dose

OTHER

Anthocyanin - food

acute single optimal dose

OTHER

Anthocyanin - placebo

acute single dose (anthocyanin free)

Sponsors & Collaborators

• University of East Anglia

  lead OTHER

Principal Investigators

• Aedin Cassidy, PhD · University of East Anglia

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Model

FACTORIAL

Eligibility

Min Age

50 Years

Max Age

75 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-02-29

Primary Completion

2013-12-31

Completion

2013-12-31

Countries

• United Kingdom

Study Locations