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Effects of Acute Intake of Flavanols on Cerebral Oxygenation and Cognition in Young Male Adults

NCT04374409 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2020-05-11

No results posted yet for this study

Summary

The study evaluates the impact of one acute dose of cocoa flavanols on brain oxygenation during a hypercapnia challenge, as well as impact on cognitive performance in young healthy males. It further assesses the impact of flavanols on peripheral vascular function, as measured by brachial Flow-mediated dilation (FMD). All participants received a high-flavanol cocoa intervention (185.5 mg of flavanols (-)-epicatechin and (+)- catechin) and a low-flavanol cocoa intervention (\< 4 mg of flavanols). It is hypothesized that the high-flavanol intervention increases cerebral oxygenation during hypercapnia and vascular function in comparison to the low-flavanol intervention.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

High-flavanol cocoa powder

Non-alkalized fat-reduced cocoa powder (Natural Acticoa)

DIETARY_SUPPLEMENT

Low-flavanol cocoa powder

Alkalized fat-reduced cocoa powder (10/12 DDP Royal Dutch)

Sponsors & Collaborators

  • University of Illinois at Urbana-Champaign

    collaborator OTHER

  • University of Birmingham

    lead OTHER

Principal Investigators

  • Catarina Rendeiro, PhD · University of Birmingham

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-02
Primary Completion
2018-12-12
Completion
2018-12-12

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04374409 on ClinicalTrials.gov