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Orange Juice Consumption and Cognitive Function

NCT01312610 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2011-11-23

No results posted yet for this study

Summary

This study is investigating the effect of 8 weeks of orange juice supplementation on executive function in healthy older adults. The study is a controled, double-blind, crossover trial and involves a 8 week supplementation with a high flavonone orange juice and a carbohydrate-matched control. Volunteers consume 500ml of either the test juice or the control juice per day for an 8 week period. There is then an 8 week washout period before subjects proceed to the other arm of the study. Subjects are randomly assigned to either arm at the beginning of the study. Measures of cognitive function will be administered pre and post both test and control interventions. Blood pressure will also be measured and blood and urine samples will be collected to assess absorption of from the juice. A sub-sample of volunteers will undergo MRI imaging pre- and post intervention to acquire cerebral blow flow information.

Conditions

  • Nerve Degeneration

Interventions

DIETARY_SUPPLEMENT

High flavanone orange juice

High flavonone orange juice drink.

DIETARY_SUPPLEMENT

Control orange juice

Orange beverage, low flavanone content, matched for total carbohydrate content, individual sugar profile, vitamin C

Sponsors & Collaborators

  • University of Reading

    lead OTHER

Principal Investigators

  • Jeremy PE Spencer, PhD · University of Reading

  • Laurie T. Butler, PhD · University of Reading

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-09-30
Primary Completion
2011-08-31
Completion
2011-09-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01312610 on ClinicalTrials.gov