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Dissecting the Roles of High-quality Diets and Ultra Processed Foods on Cardiometabolic Health

NCT06749327 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 330

Last updated 2026-05-18

No results posted yet for this study

Summary

Controversy remains around the role of ultra-processed food (UPF) consumption and health outcomes. A key question that remains to be answered is: when diet quality is the same, does food processing itself have any independent health effects? The current application aims to isolate the health effects of food processing from those of diet quality through the conduct of a dietary intervention study.

Conditions

  • Cardiometabolic Risk Factors

Interventions

BEHAVIORAL

High UPF, high hPDI diet

High ultra-processed foods (UPFs) and healthy plant based diet

BEHAVIORAL

Low UPF, high hPDI diet

Low ultra-processed foods (UPFs) and high healthy plant-based diet

Sponsors & Collaborators

  • University College Dublin

    collaborator OTHER

  • Harvard School of Public Health (HSPH)

    collaborator OTHER

  • Queen's University, Belfast

    lead OTHER

Principal Investigators

  • Prof. Lorraine Brennan, PhD · University College Dublin

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-10-01
Primary Completion
2028-12-01
Completion
2029-06-01

Countries

  • Ireland
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06749327 on ClinicalTrials.gov