Effect of Carbonated Soft Drinks on the Body Weight

Summary

Compared to solid foods, the nutritional energy of drinks may bypass the appetite regulation leading to obesity development. Although drinks sweetened with aspartame are available the anticipated positive effect of these drinks on obesity development has not been convincing. However, the mechanisms linking drinks intake to obesity are yet to be clarified.

The investigators aim is to investigate the long-term effects of intake of soft drinks, milk and water. The study is a parallel, intervention trial with 80 overweight, healthy volunteers. They will be randomly selected to drink one liter a day of one of the four drinks for six months. The objectives are changes in numerous circulating metabolic risk factors, changes in body weight, anthropometric data and fat distribution (measured by DEXA, MRI and MR-spectroscopy).

The investigators expect to clarify the mechanisms linking drinking habits to obesity development and provide scientifically based nutritional guidelines.

Conditions

• Obesity
• Metabolic; Complications
• Dietary Habits

Interventions

OTHER

Sugar-sweetened soft drink

One litre a day for six months.

OTHER

Aspartame-sweetened soft drink

One litre a day for six months.

OTHER

Semi-skimmed milk

One litre a day for six months

OTHER

Water

One litre a day for six months.

Sponsors & Collaborators

• LG Life Sciences

  collaborator INDUSTRY

• Aarhus University Hospital

  lead OTHER

Principal Investigators

• Bjørn Richelsen, Professor · Department of Internal Medicine/Endocrinology C, Aarhus University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2008-05-31

Primary Completion

2010-12-31

Completion

2010-12-31

Countries

• Denmark

Study Locations