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Physiological Effects of New Polyphenol-enriched Foods in Humans

NCT01288859 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2012-08-01

Study results available
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Summary

Polyphenolic compounds exert several health benefits depending on bioavailability. Encapsulation may improve bioavailability of these compounds.This study will evaluate bioavailability of some polyphenols (curcumin and cocoa polyphenols) from new enriched-foods. In particular bread and nut based creams will be used as food matrices to include free or encapsulated polyphenols.

Conditions

  • Healthy

Interventions

OTHER

free curcumin

free curcumin in bread, dosage 1g/100g, 200g/day per 1 day

OTHER

encapsulated curcumin

encapsulated curcumin-enriched bread, 1g/100g bread, 200g bread/day

OTHER

encapsulated curcumin + PQG

bread enriched with encapsulated curcumin plus piperine, quercetin and genistein, 1g/100g bread, 200g bread/day

OTHER

free cocoa polyphenol

nut cream enriched with free cocoa polyphenols, 1,5 g/100g cream, 100g/day per 1 day

OTHER

encapsulated cocoa polyphenols

nut cream enriched with encapsulated cocoa polyphenols, 1,5 g/100g cream, 100g/day per 1 day

OTHER

control nut cream

nut cream, cocoa polyphenols 0g/100g cream, 100 g/day per 1 day

Sponsors & Collaborators

  • Federico II University

    lead OTHER

Principal Investigators

  • Vincenzo Fogliano, Professor · University of Naples

  • Paola Vitaglione, Researcher · University of Naples

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-12-31
Primary Completion
2011-02-28
Completion
2011-07-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01288859 on ClinicalTrials.gov