A Comparative Pharmacokinetic Study to Evaluate the Ability of a New Formulation to Enhance Curcuminoids Bioavailability

Summary

The rhizome of Curcuma longa (turmeric) is commonly used as a spice and for its medicinal properties traditionally in Asian countries. Turmeric extract usually contains 95% curcuminoids with a specific ratio (approximately 75-80% curcumin, 15-20% demethoxycurcumin (DMC), and 0-10% bisdemethoxycurcumin (BDMC)).

Curcuminoids have higher solubility in organic solvents than in water. As a consequence, curcuminoids have low aqueous solubility and poor gastrointestinal absorption. They also exhibit rapid metabolism and systemic elimination and are therefore known to have limited bioavailability, which limits the use of turmeric extract in general health care and as an adjunct in managing various diseases. In order to improve the bioavailability of curcumin, several approaches have been undertaken. The use of adjuvant like piperine that interferes with glucuronidation; liposomal curcumin, nanoparticles, phospholipid complex; and structural analogues of curcumin.

Recently, Naturex has developed a dried emulsion formulation using a turmeric extract mixed together with a quillaja extract, sunflower oil and arabic gum. This formulation is highly dispersible in water and should therefore improve the bioavailability of curcuminoids. The aim of this study is to assess the bioavailability of curcuminoids and their metabolites after oral intake of 4 turmeric extract-based formulations in comparison to a standard unformulated turmeric extract.

Conditions

• Healthy

Interventions

DIETARY_SUPPLEMENT

TG

Turmipure GOLD™ 30% curcuminoids (300 mg)

DIETARY_SUPPLEMENT

STE

Standard turmeric powder extract 95% curcuminoids (1500 mg)

DIETARY_SUPPLEMENT

NOV

Novasol® Liquid micellar formulation 6% curcuminoids (1000 mg)

DIETARY_SUPPLEMENT

PHYT

Meriva® Turmeric Phytosome formulation 20% curcuminoids (1000 mg)

DIETARY_SUPPLEMENT

TEP

Turmeric extract C3 complex® 95% curcuminoids (1500mg) + BioPerine® 95% piperine (15 mg)

Sponsors & Collaborators

• Biofortis Mérieux NutriSciences

  collaborator OTHER

• Givaudan France Naturals

  lead INDUSTRY

Principal Investigators

• Pascale Fança-Berthon, PhD · Naturex

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-07-26

Primary Completion

2018-10-26

Completion

2018-10-26

Countries

• France

Study Locations