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Determination of the Bioavailability of Short Chain Fatty Acids in Healthy Humans

NCT01757379 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2015-01-14

No results posted yet for this study

Summary

The purpose of the study is to evaluate the bioavailability of acetate, propionate and butyrate in healthy humans using a stable isotope technology.

In addition the level of acetate, propionate and butyrate production from inulin will be determined using the principle of isotope dilution.

Conditions

  • Short Chain Fatty Acids Bioavailability

Interventions

DIETARY_SUPPLEMENT

13C-labeled Acetate

400 mg of sodium acetate 1-13C (2 colon delivery capsules with 200 mg)

DIETARY_SUPPLEMENT

13C-labeled propionate

340 mg of sodium propionate 1-13C (2 colon delivery capsules with 170 mg)

DIETARY_SUPPLEMENT

13C-labeled butyrate

990 mg sodium butyrate 1-13C (2 colon delivery capsules with 495 mg)

DIETARY_SUPPLEMENT

Inulin

15 g of inulin dissolved in 200 ml of water

Sponsors & Collaborators

  • KU Leuven

    lead OTHER

Principal Investigators

  • Kristin Verbeke, Professor · KU Leuven

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-04-30
Primary Completion
2012-04-30

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01757379 on ClinicalTrials.gov