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In Vitro And Ex Vivo Anti-Inflammatory Activities Of Salmon Polar Lipids

NCT03603769 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2019-12-19

No results posted yet for this study

Summary

The aim of this project is to study the effects of a new-developed food-supplement that contains bioactive polar lipids derived from organic farmed Irish salmon for the beneficial promotion of cardiovascular health. The health claims that will be formulated for this nutraceutical are based on EFSA guidelines "The scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health" and in particular paragraph 5.4, "Claims on reduced platelet aggregation" "Platelet hyperactivity and hypercoagulability states are more commonly observed in subjects with cardiovascular (CV) risk factors. Healthy subjects at very low risk of CV disease normally have non-activated circulating platelets. Decreasing platelet aggregation in subjects with platelet activation during sustained exposure to the food/constituent (e.g. four weeks) would be a beneficial physiological effect".

Within this study, the postprandial effects of this novel food supplement against platelet aggregation and inflammation are going to be exploited ex vivo in blood from human subjects as described in previously established procedures.

Conditions

Interventions

DIETARY_SUPPLEMENT

Food supplement capsules containing Salmon-Polar Lipids

Postprandial decreased Platelet activation/aggregation in subjects, after the food supplement capsule consumption

DIETARY_SUPPLEMENT

Placebo food supplement capsule

Postprandial unaffected platelet activation/aggregation in subjects, after the food supplement capsule consumption

Sponsors & Collaborators

  • University of Limerick

    lead OTHER

Principal Investigators

  • Ioannis Zabetakis, Dr · University of Limerick

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-03
Primary Completion
2018-11-30
Completion
2019-01-31

Countries

  • Ireland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03603769 on ClinicalTrials.gov