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Effects of Fructose and Exercise on Hepatic Lipid Metabolism

NCT01121003 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2011-10-19

No results posted yet for this study

Summary

8 healthy male volunteers will be studied each on 3 occasions, ie

* after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity
* after 4 days on a weight maintenance diet containing 30% fructose + low physical activity
* after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Conditions

  • Metabolism

Interventions

BEHAVIORAL

weight maintenance, low sugar diet

BEHAVIORAL

weight maintenance, high fructose diet

BEHAVIORAL

weight maintenance, high fructose diet+ exercise

Sponsors & Collaborators

  • Centre Hospitalier Universitaire Vaudois

    collaborator OTHER

  • University of Lausanne

    lead OTHER

Principal Investigators

  • Luc Tappy, MD · University of Lausanne

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-05-31
Primary Completion
2011-10-31
Completion
2011-10-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01121003 on ClinicalTrials.gov