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Fructose-induced Intestinal de Novo Lipogenesis

NCT01792089 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2019-03-25

No results posted yet for this study

Summary

8 healthy volunteers, 8 pre-bypass obese subjects, 8 subjects between 12-18 months post-bypass, and 8 subjects matched to the post-bypass patients will be studied in two sub-studies Sub-study 1) after ingestion of two or three different of the following test-meals: A)cream and whey protein B)cream, whey protein and fructose + 13C6 fructose C)test meal with cream, whey protein, fructose and glucose + 13C6 fructose Their intestinal de novo lipogenesis will be estimated by measuring 13C-palmitate on triglyceride-rich lipoprotein particles associated with apoB48 in blood Sub-study 2) after ingestion of two or three different of the following test-meals: A)cream labelled with 13C6 palmitic acid and whey protein B))cream labelled with 13C6 palmitic acid, whey protein, fructose and glucose

Their intestinal de novo lipogenesis will be estimated by measuring 13C-palmitate on triglyceride-rich lipoprotein particles associated with apoB48 in blood in sub-study 1

Their exogenous lipid absorption kinetics will be assessed by measuring 13C palmitate on triglyceride-rich lipoprotein particles associated with apoB48 in sub-study 2

Conditions

Interventions

OTHER

fat+protein meal

cream+ whey protein

OTHER

Fat + protein + 13C fructose meal

cream+ whey protein +13C fructose

OTHER

Fat+protein+13C fructose+glucose meal

Cream + whey protein + glucose:13C fructose mixture

OTHER

13C Fat + whey protein

cream labelled with 13C palmitate + whey protein

OTHER

13C Fat + whey protein + glucose+ glucose meal

cream labelled with 13C palmitate + whey protein + glucose:fructose mixture

Sponsors & Collaborators

  • University of Lausanne

    lead OTHER

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2016-12-31
Completion
2016-12-31

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01792089 on ClinicalTrials.gov