Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. Bone marrow transplantation may allow the doctor to give higher doses of chemotherapy and kill more cancer cells. Radiation therapy uses high-energy x-rays to damage cancer cells.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy, bone marrow transplantation, and radiation therapy in treating infants with acute lymphoblastic leukemia.

Conditions

• Leukemia

Interventions

BIOLOGICAL

filgrastim

DRUG

asparaginase

DRUG

cyclophosphamide

DRUG

cyclosporine

DRUG

cytarabine

DRUG

daunorubicin hydrochloride

DRUG

dexamethasone

DRUG

etoposide

DRUG

leucovorin calcium

DRUG

mercaptopurine

DRUG

mesna

DRUG

methotrexate

DRUG

methylprednisolone

DRUG

pegaspargase

DRUG

prednisone

DRUG

therapeutic hydrocortisone

DRUG

vincristine sulfate

PROCEDURE

allogeneic bone marrow transplantation

RADIATION

low-LET cobalt-60 gamma ray therapy

RADIATION

low-LET photon therapy

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Children's Oncology Group

  lead NETWORK

Principal Investigators

• Patricia A. Dinndorf, MD · Children's National Research Institute

Study Design

Purpose

TREATMENT

Eligibility

Max Age

1 Year

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1996-07-31

Primary Completion

2000-08-31

Completion

2007-03-31

Countries

• United States
• Australia
• Canada

Study Locations