Therapy Based on Stage of Disease and Risk Assessment in Treating Children With Neuroblastoma

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which treatment regimen is most effective in treating patients with different stages of and risk factors for neuroblastoma.

PURPOSE: Phase III trial to study the effectiveness of therapy based on stage of disease and risk assessment in treating children with neuroblastoma.

Conditions

• Neuroblastoma

Interventions

DRUG

carboplatin

DRUG

cisplatin

DRUG

cyclophosphamide

DRUG

dacarbazine

DRUG

doxorubicin hydrochloride

DRUG

etoposide

DRUG

ifosfamide

DRUG

melphalan

DRUG

mesna

DRUG

vincristine sulfate

DRUG

vindesine

PROCEDURE

autologous bone marrow transplantation

PROCEDURE

conventional surgery

RADIATION

low-LET cobalt-60 gamma ray therapy

RADIATION

low-LET electron therapy

RADIATION

low-LET photon therapy

RADIATION

radioisotope therapy

Sponsors & Collaborators

• Children's Hospital Medical Center, Cincinnati

  lead OTHER

Principal Investigators

• Frank Berthold, MD · Children's Hospital Medical Center, Cincinnati

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Eligibility

Max Age

20 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1990-07-31

Completion

2003-09-30

Countries

• Germany

Study Locations