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Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia

NCT00015873 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 350

Last updated 2014-02-17

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective for treating infants with acute lymphoblastic leukemia.

PURPOSE: Randomized phase III trial to compare the effectiveness of different combination chemotherapy regimens in treating infants who have newly diagnosed acute lymphoblastic leukemia.

Conditions

Interventions

DRUG

asparaginase

DRUG

cytarabine

DRUG

mercaptopurine

DRUG

methotrexate

DRUG

prednisolone

DRUG

vincristine sulfate

Sponsors & Collaborators

  • Dutch Childhood Oncology Group

    lead OTHER

Principal Investigators

  • Rob Pieters, MD, MSC, PhD · Erasmus MC-Sophia Children's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Max Age
1 Year
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1999-05-31
Primary Completion
2006-02-28
Completion
2009-12-31

Countries

  • United States
  • Austria
  • Belgium
  • Czechia
  • France
  • Germany
  • Ireland
  • Italy
  • Netherlands
  • Sweden
  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00015873 on ClinicalTrials.gov