Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug and combining drugs in different ways may kill more cancer cells.

PURPOSE: Phase II trial to study the effectiveness of chemotherapy in treating children who have very high risk acute lymphocytic leukemia.

Conditions

• Leukemia

Interventions

BIOLOGICAL

filgrastim

DRUG

asparaginase

DRUG

cyclophosphamide

DRUG

cytarabine

DRUG

daunorubicin hydrochloride

DRUG

dexamethasone

DRUG

etoposide

DRUG

idarubicin

DRUG

leucovorin calcium

DRUG

mercaptopurine

DRUG

methotrexate

DRUG

prednisone

DRUG

vincristine sulfate

RADIATION

radiation therapy

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Children's Oncology Group

  lead NETWORK

Principal Investigators

• William P. Bowman, MD · Cook Children's Medical Center - Fort Worth

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Max Age

17 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1999-03-31

Primary Completion

2002-11-30

Completion

2007-03-31

Countries

• United States
• Canada
• Netherlands
• Puerto Rico
• Switzerland

Study Locations