Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia
NCT00049569 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 126
Last updated 2013-10-08
Summary
Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Imatinib mesylate may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. Combining more than one chemotherapy drug with imatinib mesylate may kill more cancer cells. Randomized phase II trial to study the effectiveness of combination chemotherapy and imatinib mesylate in treating children who have relapsed acute lymphoblastic leukemia.
Conditions
- L1 Childhood Acute Lymphoblastic Leukemia
- L2 Childhood Acute Lymphoblastic Leukemia
- Non-T, Non-B Childhood Acute Lymphoblastic Leukemia
- Recurrent Childhood Acute Lymphoblastic Leukemia
- T-cell Childhood Acute Lymphoblastic Leukemia
Interventions
- DRUG
-
Given IT
- DRUG
-
methotrexate
Given IT
- DRUG
-
vincristine sulfate
Given IV
- DRUG
-
Given PO
- DRUG
-
pegaspargase
Given IM
- DRUG
-
doxorubicin hydrochloride
Given IV
- DRUG
-
imatinib mesylate
Given PO
- DRUG
-
Given IV
- DRUG
-
etoposide
Given IV
- BIOLOGICAL
-
Given SC
- DRUG
-
leucovorin calcium
Given IV
- DRUG
-
asparaginase
Given IM
- DRUG
-
therapeutic hydrocortisone
Given IT
Sponsors & Collaborators
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
Elizabeth Raetz · Children's Oncology Group
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 1 Year
- Max Age
- 21 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2003-01-31
- Primary Completion
- 2006-03-31
Countries
- United States
Study Locations
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