Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma

NCT00003728 · Status: UNKNOWN · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 1500

Last updated 2011-01-21

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy plus steroid therapy is more effective for acute lymphoblastic leukemia or lymphoblastic non-Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of different regimens of combination chemotherapy plus steroid therapy in treating children who have acute lymphoblastic leukemia or lymphoblastic non-Hodgkin's lymphoma.

Conditions

Interventions

DRUG: asparaginase
DRUG: cyclophosphamide
DRUG: cytarabine
DRUG: daunorubicin hydrochloride
DRUG: dexamethasone
DRUG: doxorubicin hydrochloride
DRUG: etoposide
DRUG: leucovorin calcium
DRUG: mercaptopurine
DRUG: methotrexate
DRUG: methylprednisolone
DRUG: mitoxantrone hydrochloride
DRUG: prednisolone
DRUG: therapeutic hydrocortisone
DRUG: thioguanine
DRUG: vincristine sulfate
DRUG: vindesine
PROCEDURE: allogeneic bone marrow transplantation
PROCEDURE: peripheral blood stem cell transplantation

Sponsors & Collaborators

European Organisation for Research and Treatment of Cancer - EORTC
lead NETWORK

Principal Investigators

Jacques Otten, MD · Academisch Ziekenhuis der Vrije Universiteit Brussel

Study Design

Allocation: RANDOMIZED
Purpose: TREATMENT

Eligibility

Max Age: 17 Years
Sex: ALL
Healthy Volunteers: No

Timeline & Regulatory

Start: 1998-12-31
Primary Completion: 2008-05-31

Countries

Belgium
France
Portugal

Study Locations

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Entities

Drugs

Diseases