Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia
NCT00002812 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 2078
Last updated 2013-08-26
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug and giving the drugs in different combinations may kill more cancer cells.
PURPOSE: Randomized phase III trial to compare the effectiveness of standard combination chemotherapy treatment with more intensive combination chemotherapy in treating children with acute lymphocytic leukemia.
Conditions
Interventions
- DRUG
-
asparaginase
Given IV
- DRUG
-
Given IV
- DRUG
-
Given IV
- DRUG
-
daunorubicin hydrochloride
Given IV
- DRUG
-
Given IV
- DRUG
-
doxorubicin hydrochloride
Given IV
- DRUG
-
idarubicin
Given IV
- DRUG
-
mercaptopurine
Given IV
- DRUG
-
methotrexate
Given PO
- DRUG
-
pegaspargase
Given IV
- DRUG
-
Given PO
- DRUG
-
thioguanine
Given IV
- DRUG
-
vincristine sulfate
Given IV
- RADIATION
-
radiation therapy
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Children's Oncology Group
lead NETWORK
Principal Investigators
-
Nita L. Seibel, MD · Children's National Research Institute
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 1 Year
- Max Age
- 21 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1996-09-30
- Primary Completion
- 2006-03-31
Countries
- United States
- Australia
- Canada
Study Locations
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