Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia

Summary

Phase II trial to study the effectiveness of radiation therapy following chemotherapy in treating children with CNS relapse from acute lymphoblastic leukemia. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with radiation therapy may kill more cancer cells.

Conditions

• Leukemia

Interventions

BIOLOGICAL

filgrastim

DRUG

asparaginase

DRUG

cyclophosphamide

DRUG

daunorubicin hydrochloride

DRUG

dexamethasone

DRUG

etoposide

DRUG

leucovorin calcium

DRUG

liposomal cytarabine

DRUG

mercaptopurine

DRUG

mesna

DRUG

methotrexate

DRUG

therapeutic hydrocortisone

DRUG

thiotepa

DRUG

vincristine sulfate

RADIATION

low-LET electron therapy

RADIATION

low-LET photon therapy

Sponsors & Collaborators

• National Cancer Institute (NCI)

  lead NIH

Principal Investigators

• Julio C. Barredo, MD · Medical University of South Carolina

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Max Age

20 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1996-01-31

Primary Completion

2004-06-30

Countries

• United States
• Canada
• Puerto Rico
• Switzerland

Study Locations