Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia
NCT00002816 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 120
Last updated 2013-08-22
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
PURPOSE: Phase III trial to compare the effectiveness of combination chemotherapy in treating children who have relapsed acute lymphoblastic leukemia.
Conditions
Interventions
- DRUG
-
Given IV
- DRUG
-
Given IV
- DRUG
-
etoposide
Given IV
- DRUG
-
idarubicin
Given IV
- DRUG
-
ifosfamide
Given IV
- DRUG
-
leucovorin calcium
- DRUG
-
mesna
Given IV
- DRUG
-
pegaspargase
Given IV
- DRUG
-
therapeutic hydrocortisone
- DRUG
-
thioguanine
- DRUG
-
vincristine sulfate
Given IV
- RADIATION
-
low-LET cobalt-60 gamma ray therapy
- RADIATION
-
low-LET electron therapy
- RADIATION
-
low-LET photon therapy
- DRUG
-
Methotrexate
Given IV
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Children's Oncology Group
lead NETWORK
Principal Investigators
-
Michael L.N. Willoughby, MD · Princess Margaret Hospital for Children
Study Design
- Purpose
- TREATMENT
Eligibility
- Max Age
- 20 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1996-12-31
- Primary Completion
- 2002-11-30
- Completion
- 2006-04-30
Countries
- United States
- Australia
- Canada
Study Locations
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