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Impact of Smoking on Immune Responses in Peri-implant Health and Disease

NCT07750171 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 216

Last updated 2026-08-06

No results posted yet for this study

Summary

Peri-implant diseases are inflammatory conditions affecting the gums and bone around dental implants. Peri-implant mucositis causes inflammation in the gums, while peri-implantitis can also lead to bone loss and, in severe cases, implant failure. Smoking is an important risk factor for these conditions because it may change how the immune system responds to inflammation and infection.

This study will compare smokers and non-smokers with healthy dental implants, peri-implant mucositis, or peri-implantitis. Fluid samples will be collected from around the implants to measure proteins involved in inflammation, healing, and immune responses. The aim is to better understand how smoking affects the body's response to peri-implant diseases and to identify biological markers that may help assess disease risk and severity in the future.

Conditions

  • Peri-Implant Health
  • Peri Implant Mucositis
  • Peri-implantitis

Sponsors & Collaborators

  • University of Turku

    collaborator OTHER

  • Gazi University

    lead OTHER

Principal Investigators

  • Buse Naz Büyükakçalı, DDS · Gazi University

Eligibility

Min Age
21 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2026-10-01
Completion
2026-12-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07750171 on ClinicalTrials.gov