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The Effect of Smoking on Peri-implantitis

NCT06150066 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 96

Last updated 2025-07-20

No results posted yet for this study

Summary

the primary aim of this project is to evaluate the microbiological and inflammatory effect of smoking status and smoking severity on periimplantitis lesions. The secondary aim is to compare the effect of smoking on periimplantitis and periodontal microbiota and inflammation in the same individuals.

There will include 96 patients, equally divided into four groups: Smokers with peri-implantitis (n=24), non-smoker individuals with peri-implantitis (n=24), smokers with healthy peri-implant tissues (n=24), non-smoker individuals with healthy peri-implant tissues (n=24).

Microbiological and biochemical analyses will be performed on the samples taken.

Conditions

  • Periimplantitis
  • Microbial Colonization
  • Cytokines

Interventions

OTHER

Recruiting samples

The GCF, plaque, and saliva samples will recruited from participants.

Sponsors & Collaborators

  • University of Bern

    collaborator OTHER

  • Dokuz Eylul University

    collaborator OTHER

  • Gazi University

    collaborator OTHER

  • Mustafa Kemal University

    lead OTHER

Principal Investigators

  • Alpdogan Kantarci, Prof · Forsyth Institute

  • Anton Sculean, Prof · University of Bern

  • Berrin Unsal, Prof · Gazi University

  • Aliye Akcali, Prof · Dokuz Eylul University

  • Aysegul Sari, PhD · Mustafa Kemal University

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-21
Primary Completion
2024-07-01
Completion
2026-12-21

Countries

  • Switzerland
  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06150066 on ClinicalTrials.gov