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Evaluation of the Effect of Smoking on Pyroptosis in Periodontal Pathogenesis

NCT07563192 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 113

Last updated 2026-05-01

No results posted yet for this study

Summary

This study investigates the impact of smoking on pyroptosis and inflammatory signaling pathways in systemically healthy individuals with various periodontal conditions. The research compares smokers and non-smokers across three clinical categories, resulting in six study groups: Healthy Control, Gingivitis, and Periodontitis. The study specifically evaluates the levels of IL-1beta, IL-18, and NLRP3 through ELISA, and the gene expression of TLR1, TLR4, and TLR6 through RT-PCR, to understand how cigarette smoke modulates innate immune responses in the absence of other systemic diseases.

Conditions

  • Periodontitis
  • Gingivitis
  • Periodontal Diseases
  • Smoking ( Cigarette)

Sponsors & Collaborators

  • Suleyman Demirel University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-10-15
Primary Completion
2025-11-18
Completion
2026-06-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07563192 on ClinicalTrials.gov