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Effects of Smoking on Oral Tissue Samples

NCT05484765 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2023-09-28

No results posted yet for this study

Summary

Smoking negatively affects the prognosis of periodontal disease by impairing tissue healing. While micronucleus is the most popular parameter for demonstrating DNA damage, inflammatory cell and vascular densities are the most evaluated parameters for determining histopathologic changes in the periodontium. This cross-sectional study aimed to evaluate the effects of heavy cigarette smoking and generalized periodontitis on local genotoxic damage to exfoliated oral epithelial cells as well as histopathologic damage to the periodontium. The investigators hypothesized that the genotoxic and histopathologic damage would be increased in smokers with generalized periodontitis.

Conditions

  • Histopathology
  • Periodontitis
  • Smoking
  • Micronuclei

Sponsors & Collaborators

  • Istanbul Medipol University Hospital

    lead OTHER

Principal Investigators

  • Begum Alkan · Private Practice of Periodontology (formerly Istanbul Medipol University)

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-11-01
Primary Completion
2019-07-15
Completion
2019-07-20

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05484765 on ClinicalTrials.gov