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Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35

NCT05281848 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 55

Last updated 2022-03-16

No results posted yet for this study

Summary

Periodontal diseases are among the major causes of tooth loss. Smoking may play a role as a contributing factor in the development of periodontitis by reducing the immune response. The role of cytokines in the pathogenesis of periodontal disease is clearly indicated in the literature; it has been shown that microorganisms that cause periodontal disease cause cytokine increase in saliva, gingival tissue and gingival crevicular fluid. Among these cytokines, interleukin (IL) -17 is proinflammatory and IL-35 is antiinflammatory and has been associated with periodontal disease.

Conditions

  • Periodontitis
  • Periodontal Diseases
  • Smoking
  • Smoking, Tobacco

Interventions

PROCEDURE

Non-surgical periodontal treatment

Non-surgical periodontal treatment includes periodontal prophylaxis and root planning. No other methods or any of drugs will be used.

Sponsors & Collaborators

  • Gazi University

    lead OTHER

Principal Investigators

  • Gülay Tüter, Professor · Gazi University Dentistry Faculty Department of Periodontology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2019-06-01
Completion
2022-03-07

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05281848 on ClinicalTrials.gov