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Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy

NCT06145685 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2023-11-24

No results posted yet for this study

Summary

The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease. This is to assess the period of smoking abstinence needed before any periodontal surgery in order to reverse the negative effects of the reported increased levels of inflammatory markers (IL-1β and PGE2 in this study) associated with smoking on the healing and the periodontium.

Conditions

  • Periodontal Diseases
  • Smoking Cessation

Interventions

PROCEDURE

Minimally invasive non-surgical periodontal therapy

Minimally invasive non-surgical periodontal therapy

PROCEDURE

Conventional non-surgical periodontal therapy

Conventional non-surgical periodontal therapy

Sponsors & Collaborators

  • Ain Shams University

    collaborator OTHER

  • Misr University for Science and Technology

    collaborator OTHER

  • October 6 University

    lead OTHER

Principal Investigators

  • Noura M ElShiaty, Dr. · Master Degree in Diagnosis, Oral Medicine and Periodontology - Faculty of Dentistry - Ain Shams University, Membership of the Faculty of Dental Surgery of The Royal College of Surgeons of Edinburgh

  • Fatma H El-Demerdash, Associate Professor · Associate Professor of Periodontology, Oral Medicine and Diagnosis - Faculty of Dentistry - Ain Shams University, Associate Professor of Oral Medicine and Periodontology - Faculty of Oral and Dental Medicine - Misr International University

  • Hussien Elkholy, Associate Professor · Associate Professor of Psychiatry - Faculty of Medicine - Ain Shams University

  • Ahmed Y Gamal, Professor · Professor of Oral Medicine, Periodontology and Oral Diagnosis - Faculty of Dentistry - Ain Shams University, Professor of Periodontology - College of Oral and Dental Surgery - Misr University for Science and Technology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2022-02-28
Completion
2022-02-28

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06145685 on ClinicalTrials.gov