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Effect of Non-surgical Treatment of Periodontitis Patients Focusing on Inflammatory Mediators in Gingival Crevicular Fluid

NCT07503041 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2026-03-31

No results posted yet for this study

Summary

This study investigates inflammatory biomarkers in gingival crevicular fluid (GCF) from smokers and non-smokers with severe periodontitis, before and during non-surgical periodontal therapy (NSPT). During periodontal disease development the periodontal pockets become deeper. In the inflamed periodontal tissue the interstitial fluid is filtered out into the periodontal pocket. The GCF reflects local inflammatory activity and contains cytokines/chemokines that may serve as biomarkers for disease severity and treatment response.

Investigators aim at collecting GCF from periodontal pockets from each patients before and during NSPT. Investigators compare non-smokers and smokers. The samples will be analysed for pro-inflammatory mediators and investigators aim at biomarkers that are at a high level in deep inflamed periodontal pockets. Investigators also want to observe if these biomarkers are altered in GCF after periodontal therapy. Finally investigators want to compare non-smokers and smokers with respect to treatment outcome and respons of chemokines/cytokines in GCF.

Conditions

  • Periodontitis
  • Periodontitis Chronic Generalized Severe

Interventions

OTHER

Collecting fluid for biomarker analyses

We are looking at spesific biomarkers in GCF that has not been investigated before

PROCEDURE

Hygiene instruction, tooth cleaning, plaque removal

Sponsors & Collaborators

  • Oral Health Centre of Expertise in Western Norway

    lead OTHER

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-08
Primary Completion
2025-12-21
Completion
2025-12-21

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07503041 on ClinicalTrials.gov