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Gut, Immune, and Vascular Health in Metabolically Healthy Obesity

NCT07559227 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2026-04-30

No results posted yet for this study

Summary

The investigators seek to better understand how a single high-fat meal impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity" (obesity and largely normal cardiometabolic profile) and "metabolically healthy normal-weight individuals." Second, the investigators seek to understand how a prebiotic fiber (inulin) impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity."

Conditions

  • Metabolically Healthy Obesity

Interventions

DIETARY_SUPPLEMENT

Inulin Supplementation

Half of participants in part 2 will recieve supplemental inulin or placebo (maltodextrin).

DIETARY_SUPPLEMENT

Maltodextrin (Placebo)

Half of participants in part 2 will recieve supplemental inulin or placebo (maltodextrin).

OTHER

High-fat meal

All participants in part 1 (both metabolically healthy normal weight and metabolically healthy obesity) will consume a high-fat meal designed to invoke changes in gut, immune, and vascular parameters.

Sponsors & Collaborators

  • Ball State University

    lead OTHER

Principal Investigators

  • Bryant Keirns, PhD · Ball State University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-01
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07559227 on ClinicalTrials.gov