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Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF)

NCT07213245 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2025-12-15

No results posted yet for this study

Summary

The overall aim of this project is to study the effects of short-term high ultra-processed food intake, compared to nutrient- and energy density matched low ultra-processed food (UPF) intake, on energy intake and appetite.

A total of 24 men and women who meet all inclusion criteria and none of the exclusion criteria will be invited to participate. A randomized 2\*2 factorial four-way crossover study will be conducted at the Department of Internal medicine and Clinical Nutrition at the University of Gothenburg, comparing a high-UPF meal to a low-UPF meal also with high and/or low energy density. A supervised breakfast meal will be served, and postprandial blood samples and appetite measures will be collected continuously up to 4 hours after the breakfast meal. Subsequently, an ad libitum lunch meal will be served, and energy intake will be recorded.

Conditions

  • Appetite
  • Obesity and Obesity-related Medical Conditions

Interventions

OTHER

Meal high in energy density, high in ultra-processed food

Meal high in energy density, high in ultra-processed food

OTHER

Meal high in energy density, low in ultra-processed food

Meal high in energy density, low in ultra-processed food

OTHER

Meal low in energy density, high in ultra-processed food

Meal low in energy density, high in ultra-processed food

OTHER

Meal low in energy density, low in ultra-processed food

Meal low in energy density, low in ultra-processed food

Sponsors & Collaborators

  • Göteborg University

    lead OTHER

Principal Investigators

  • Therese Karlsson, PhD · University of Gothenburg, Institute of medicine

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2026-04-30
Completion
2026-04-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07213245 on ClinicalTrials.gov