Effect of Ilex Paraguariensis Harvest Time and Consumption Method of Processed Yerba Mate on the Lipid Profile

Summary

Introduction: This project studies the impact of Ilex paraguariensis harvest time, commonly known as yerba mate, and its consumption mode (mate, tereré, and mate/terere) on the lipid profile of consumers in the Department of Caaguazú, Paraguay. Yerba mate is rich in bioactive compounds such as polyphenols, xanthines, and saponins. There are no clinical trials conducted in Paraguay with our Ilex paraguariensis plantations that have analyzed the influence of harvest time on the yerba mate production process and the infusion mode, in relation to its effect on dyslipidemias. General Objective: To establish the effectiveness of Ilex paraguariensis harvest time and the mode of consumption of the produced yerba mate on the lipid profile of consumers in the Department of Caaguazú, Paraguay. Methodology: The research approach will be quantitative, using a triple-blind randomized clinical trial design. Participants will be regular consumers of yerba mate, divided into groups based on harvest time (beginning or end of the harvest) and consumption mode (mate, tereré, or both). Lipid profile measurements will be taken at baseline and at 30, 90, and 180 days after consumption. Yerba mate samples will be analyzed and classified according to their bioactive properties before being blinded to the researchers and participants. Expected results: a report on the social, cultural, and anthropometric characterization of regular consumers of mate and tereré, and a report on the concentrations of the bioactive properties of yerba mate; polyphenols, xanthines, saponins from Ilex paraguariensis harvested at the beginning and end of the harvest and the database of patients with baseline lipid profile results, at 30, 90, and 180 days of mate and tereré consumers with yerba mate prepared randomly according to the harvest time of the Ip (beginning or end of harvest) analyzed.

Conditions

• Lipid Metabolism Disorders

Interventions

DIETARY_SUPPLEMENT

Yerba mate consumption (Ilex paraguayensis) A

Yerba mate of the begining of the harvest time

DIETARY_SUPPLEMENT

Yerba mate comsuption (ilex paraguayencis) B

Yerba mate of the final time of the harvest

Sponsors & Collaborators

• Hospital Nacional de Itaugua, MSPyBS, Paraguay)

  collaborator UNKNOWN

• Instituto Nacional de Salud, Paraguay

  collaborator OTHER

• Universidad de La Frontera

  collaborator OTHER

• McMaster University

  collaborator OTHER

• Universidad del Cauca

  collaborator OTHER

• Universidad Nacional de Caaguazu

  lead OTHER

Principal Investigators

• Guiomar Viveros · Universidad Nacional de Caaguazu, Facultad de Ciencias de la Salud

• Gloria Gonzalez · Universidad Nacional de Caaguazu, Facultad de Ciencias de la Salud

• Angel Rolon · Universidad Nacional de Caaguazu, Facultad de Ciencias de la Salud

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-02-01

Primary Completion

2026-08-01

Completion

2026-10-01

Countries

• Paraguay

Study Locations