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Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

NCT06628349 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-11-25

No results posted yet for this study

Summary

The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.

Conditions

  • Protein Metabolism

Interventions

DIETARY_SUPPLEMENT

Whey Protein Isolate 90%

Commercially available animal based protein powders

DIETARY_SUPPLEMENT

Soy Protein Isolate (90% Protein)

Commercially available plant based protein powders

DIETARY_SUPPLEMENT

Organic Pea Protein Isolate

Commercially available plant based protein powders

DIETARY_SUPPLEMENT

Placebo (Water)

Normal drinking water

Sponsors & Collaborators

Principal Investigators

  • Marielle Engelen, PhD · Texas A&M University

  • Nicolaas Deutz, MD, PhD · Texas A&M University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-02-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06628349 on ClinicalTrials.gov