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Biomarker Identification and Nutritional Intervention of Primary Sarcopenia Based on Gut-muscle Axis

NCT06347835 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2024-04-22

No results posted yet for this study

Summary

The loss of skeletal muscle mass and function usually occurs with aging, known as primary sarcopenia. Sarcopenia has a prevalence of 11.6% among the elderly population in China and is closely associated with increased risks of falls, disability, and mortality. Currently, there is a lack of definition criteria for sarcopenia based on biomarkers. The Gut-Muscle Axis hypothesis suggests a complex interplay between gut microbiota and skeletal muscle. Nutritional intervention targeting the gut microbiota potentially plays a significant role in muscle regeneration. Therefore, this study aims to explore the effects of symbiotic and whey protein on muscle, gut microbiota, and clinical outcomes among sarcopenia patients, to provide a reference for further diagnosis and treatment of sarcopenia.

Conditions

Interventions

DIETARY_SUPPLEMENT

symbiotic

The intervention is made up of multiple probiotics and prebiotics (20g/d) and dietary pattern modification.

DIETARY_SUPPLEMENT

whey protein

The intervention is made up of whey protein supplements (20g/d) and dietary pattern modification.

DIETARY_SUPPLEMENT

symbiotic placebo

The intervention is made up of maltodextrin (20g/d) and dietary pattern modification.

DIETARY_SUPPLEMENT

whey protein placebo

The intervention is made up of maltodextrin (20g/d) and dietary pattern modification.

Sponsors & Collaborators

  • Peking Union Medical College Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-04-30
Primary Completion
2025-04-30
Completion
2026-01-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06347835 on ClinicalTrials.gov