MedTrace Logo

Hydrolyzed Casein and Whey Protein Supplementation and the Addition of Leucine to Induce Protein Anabolism in Malnourished COPD Patients

NCT01154400 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2012-10-15

No results posted yet for this study

Summary

The aim of this study is the first aim of a NIH project that consists of 3 aims. The first aim examines the acute effects of two high-quality milk proteins (casein vs. whey) on whole-body and muscle protein metabolism in COPD patients with severe loss of muscle mass and the effects of adding leucine. The principal endpoints will be the extent of stimulation of net whole body protein synthesis as this is the principal mechanism by which either amino acid or protein intake causes muscle anabolism. After determining the optimal nutritional formulation based on the first aim we will continue to work on the second and third aim where fish oil supplementation will be part of the nutritional intervention as well.

Conditions

Interventions

DIETARY_SUPPLEMENT

Casein protein hydrolysates

15 g casein protein hydrolysates + 15 g maltodextrin

DIETARY_SUPPLEMENT

Whey protein hydrolysates

15 g whey protein isolate + 15 g maltodextrin

DIETARY_SUPPLEMENT

Casein protein hydrolysates + LEU

15 g casein protein hydrolysate + 2.1 g LEU (40% of EAA content) + 15 g maltodextrin

DIETARY_SUPPLEMENT

Whey protein hydrolysates + LEU

15 g whey protein isolate + 1.5 g LEU (40% of EAA content) + 15 g maltodextrion

Sponsors & Collaborators

Principal Investigators

  • Marielle Engelen, PhD · Texas A&M University

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-05-31
Primary Completion
2011-07-31
Completion
2011-07-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01154400 on ClinicalTrials.gov