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Protein Restriction (PR) for Weight Loss

NCT06263725 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2024-02-16

No results posted yet for this study

Summary

Prolonged dietary protein restriction has been shown to increase energy expenditure in mice simultaneously with an increase in plasma FGF21 levels. In overfeeding studies, a protein-restricted diet reduces weight gain in both mice and humans compared with normal and high-protein diets. Further, in energy balance studies, when lean men are provided with a protein-restricted diet for five weeks, an increase in energy intake was necessary to obtain their body weight. However, whether the effect of a protein-restricted diet is the same when consumed by overweight to obese men has divergent results in both mice and humans.

Conditions

  • Diet, Healthy, Body Weight

Interventions

OTHER

Restricted dietary protein

Participants will be allocated to 5 week isocaloric restricted protein intake

OTHER

Habitual diet

Participants will be follow their habitual, high protein intake

Sponsors & Collaborators

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Bente Kiens, D.Sci · University of Copenhagen

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2023-12-31
Completion
2023-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06263725 on ClinicalTrials.gov