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Effects of Exercise & Tart Cherry Ingestion on Heat Acclimation and Gut Microbiome

NCT05281198 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 4

Last updated 2023-10-16

No results posted yet for this study

Summary

The purpose of this study is to determine whether tart cherry supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress.

Specific Aim I. To determine if tart cherry in combination with repeated bouts of thermally stressful exercise will impact the gut microbiome \& inflammation measured via stool sample \& blood samples for plasma endotoxin, inflammatory cytokines and HSP.

Specific Aim II. To determine whether whole body hyperthermia causes changes in bacterial populations in the gut microbiome, and if these changes are affected by washout or re-acclimation.

Specific Aim III. To determine whether tart cherry supplementation suppresses the ability of human subjects to acclimate to exercise/heat stress. This will be assessed via body temperature, heart rate, sweat and plasma volume responses, and exercise performance during standardized heat tolerance tests.

Conditions

  • Heat Acclimation and Thermotolerance

Interventions

DIETARY_SUPPLEMENT

tart cherry juice

2, 8oz bottles of Montmorency tart cherry juice daily; 8oz taken in AM, 8oz taken in PM

DIETARY_SUPPLEMENT

Placebo

2, 8oz bottles of placebo juice daily; 8oz taken in AM, 8oz taken in PM

Sponsors & Collaborators

  • Ohio University

    lead OTHER

Principal Investigators

  • Angela Hillman, PhD · Division of Exercise Physiology

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-26
Primary Completion
2023-04-30
Completion
2023-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05281198 on ClinicalTrials.gov