Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health

Summary

The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity and associated metabolic health disorders. The gut microbiota compositions plays a decisive role in glucose metabolism and the chronic inflammatory state associated with insulin resistance. Consuming prebiotic rich diet, including polyphenol and inulin rich food could help modulate favorably the gut microbiota which could lead to a reduction of endotoxemia and beneficial metabolic health effects.

Conditions

• Endotoxemia
• Metabolic Syndrome
• Glucose Metabolism Disorders
• Insulin Resistance

Interventions

DIETARY_SUPPLEMENT

Cranberry

Supplementation of polyphenols from cranberry extract

DIETARY_SUPPLEMENT

Agaves

Supplementation of inulin from Agaves powder

DIETARY_SUPPLEMENT

Placebo

Supplementation with placebo

Sponsors & Collaborators

• Ministry of Agriculture, Fisheries and Food, Quebec

  collaborator OTHER_GOV

• Ministry of economic development, innovation and export trade, Quebec

  collaborator UNKNOWN

• Diana Food, Symrise

  collaborator UNKNOWN

• Atrium Innovations

  collaborator INDUSTRY

• NutriAgaves, Mexico

  collaborator UNKNOWN

• Société des Produits Nestlé (SPN)

  collaborator INDUSTRY

• Laval University

  lead OTHER

Principal Investigators

• Hélène Jacques, PhD · Institute of nutrition and functional foods, Laval University

• Yves Desjardins, PhD · Institute of nutrition and functional foods, Laval University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-11-05

Primary Completion

2020-12-31

Completion

2021-12-31

Countries

• Canada

Study Locations