Exploring the Comorbidity Between Mental Disorders and General Medical Conditions

Summary

Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions). The investigators aim to undertake a comprehensive study of comorbidity among those with treated mental disorders, by using high-quality Danish registers to provide age- and sex-specific pairwise estimates between the ten groups of mental disorders and nine groups of general medical conditions.

The investigators will examine the association between all 90 possible pairs of prior mental disorders and later GMC categories using the Danish national registers. Depending on whether individuals are diagnosed with a specific mental disorder, the investigators will estimate the risk of receiving a later diagnosis within a specific GMC category, between the start of follow-up (January 1, 2000) or at the earliest age at which a person might develop the mental disorder, whichever comes later. Follow-up will be terminated at onset of the GMC, death, emigration from Denmark, or December 31, 2016, whichever came first. Additionally for dyslipidemia, follow-up will be ended if a diagnosis of ischemic heart disease was received. A "wash-out" period will be employed in the five years before follow-up started (1995-1999), to identify and exclude prevalent cases from the analysis. Individuals with the GMC of interest before the observation period will be considered prevalent cases and excluded from the analyses (i.e. prevalent cases were "washed-out"). When estimating the risk of a specific GMC, the investigators will consider all individuals to be exposed or unexposed to the each mental disorder depending on whether a diagnosis is received before the end of follow-up. Persons will be considered unexposed to a mental disorder until the date of the first diagnosis, and exposed thereafter.

Conditions

• Organic, Including Symptomatic, Mental Disorders
• Substance Use
• Schizophrenia
• Mood [Affective] Disorders
• Neurotic, Stress-related and Somatoform Disorders
• Eating Disorder
• Disorders of Adult Personality and Behavior
• Mental Retardation
• Disorder of Psychological Development
• Behavioural Disorder
• Hypertension
• Dyslipidemias
• Ischemic Heart Disease
• Atrial Fibrillation
• Heart Failure
• Peripheral Occlusive Disease
• Stroke
• Diabetes Mellitus
• Thyroid Disorder
• Gout
• Chronic Pulmonary Disease
• Allergy
• Chronic Gastritis
• Chronic Liver Disease
• Inflammatory Bowel Diseases
• Diverticular Disease of Large Intestine
• Chronic Kidney Diseases
• Prostate Disorders
• Connective Tissue Disorder
• Osteoporosis
• Pain
• HIV/AIDS
• Anemia
• Cancer
• Vision Disorders
• Hearing Disorders
• Migraine
• Epilepsy
• Parkinson Disease
• Multiple Sclerosis
• Neuropathy

Interventions

OTHER

Organic Disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Substance Use Disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Schizophrenia Disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Mood disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Neurotic disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Eating Disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Personality Disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Intellectual Disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Developmental Disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

OTHER

Behavioral Disorders

Individuals were considered to have a specific mental disorder from the date they received a relevant diagnosis registered in the Danish Psychiatric Central Research Register.

Sponsors & Collaborators

• University of Aarhus

  lead OTHER

Principal Investigators

• John J McGrath, MD, PhD · National Centre for Register-Based Research, Aarhus University

Eligibility

Min Age

1 Year

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2000-01-01

Primary Completion

2016-12-31

Completion

2020-01-31