Anemia is a condition in which the blood has a reduced number of red blood cells or hemoglobin, leading to decreased oxygen-carrying capacity and symptoms such as fatigue and weakness.
AbbVie will present new lung cancer data at WCLC 2026, including Phase 1b results for ABBV-1480 showing high response rates in NSCLC and safety updates for ABBV-706 in SCLC. The company also reported progress in dermatology, obesity, and Crohn's disease programs.
Keros Therapeutics plans a phase II DMD trial of rinvatercept in Q1 2026 and regulatory talks for ALS in H2 2026. Cash stands at $383 million with runway into H1 2028.
The FDA has approved Agios Pharmaceuticals' mitapivat (AQVESME) as the first oral treatment for anemia in thalassemia, reducing transfusion needs by 40-50%. Meanwhile, a clinical trial found a three-times-weekly dosing of vadadustat (Vafseo) is safe for kidney dialysis patients, potentially improving convenience.
Daraxonrasib reduced death risk by 60% versus chemo in Phase 3 pancreatic cancer trial (median OS 13.2 vs 6.7 months). EMA began rolling review; zoldonrasib combo data presented at ESMO GI.
Epcoritamab plus lenalidomide cut progression risk by 60% in R/R DLBCL in a phase 3 trial. Five-year AUGMENT follow-up supports R2 in indolent NHL; a phase 2 penpulimab-lenalidomide-R-GemOx trial showed activity in DLBCL.
Recent research highlights advances in managing hemolytic disease of the fetus and newborn (HDFN). A meta-analysis found that combining phototherapy with certain adjunctive drugs like clofibrate may improve bilirubin reduction. Other studies emphasize the importance of preconception stability for women with rare diseases and the clinical impact of rare maternal antibodies.
Two separate clinical trials have reported advances in cancer care. An oral drug combination of decitabine-cedazuridine and venetoclax showed efficacy in older patients with acute myeloid leukemia, with a 47% complete response rate in a phase 2b trial. A separate randomized controlled trial found that delaying pegfilgrastim administration to 72 hours post-chemotherapy significantly reduced bone pain in women with stage I–III breast cancer.
A phase II trial of TAK-007 CAR-NK therapy in R/R B-cell NHL showed a 60.9% overall response rate. Preclinical CAR-NKT therapy eliminated endometrial tumors in models. Optimized costimulatory domains (2B4-DAP12) boosted CAR-NK tumor killing.
A study of over 1.1 million births found a U-shaped relationship between early pregnancy hemoglobin levels and severe neonatal morbidity and mortality, with both anemia and erythrocytosis increasing risk.
New AI tools predict diabetic kidney disease from retinal images, flag hemodialysis patients at hospitalization risk, and advance lupus nephritis care. Findings were presented at ARVO 2026 and published in NEJM Catalyst, The Lancet, and the International Journal of Molecular Sciences.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07781540 |
Iron Deficiency at ICU Discharge |
RECRUITING | |
| NCT07771192 |
Study Evaluating Multifaceted Support for the Implementation of Recommendations for the Prevention and Management of Anemia in Intensive Care Units |
NOT_YET_RECRUITING | |
| NCT07761832 |
Hemoglobin Trends as a Predictor of Outcomes in Critically Ill Patients (The TRENT-ICU Study) |
COMPLETED | |
| NCT07761104 |
Phenotyping Acute Non-Severe Anemia in the Emergency Department |
NOT_YET_RECRUITING | NA |
| NCT07738510 |
Evaluate Ofirnoflast in Adults With Very Low- to Intermediate-risk Myelodysplastic Syndromes Requiring Transfusions |
NOT_YET_RECRUITING | PHASE2 |
| NCT07725497 |
A Study of Luspatercept in People With Anemia |
RECRUITING | PHASE2 |
| NCT07715318 |
Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia. |
NOT_YET_RECRUITING | PHASE2 |
| NCT07708025 |
Oral Iron for the Management of Iron Deficiency Anemia in SGLT2i-Treated Heart Failure Patients |
COMPLETED | PHASE3 |
| NCT07701499 |
Validation of Non-Invasive Hemoglobin Measurement Using Optical Method for Anemia Screening Among Adults in Jakarta |
NOT_YET_RECRUITING | |
| NCT07699666 |
Delayed Versus Immediate Cord Clamping in Preterm Birth |
RECRUITING | NA |
