Also known as: HF
Heart failure is a serious clinical syndrome in which the heart cannot pump enough blood and oxygen to meet the body’s needs. It is a chronic condition with episodic decompensation and can cause dyspnea, edema, fatigue, and repeated hospitalizations. Early diagnosis and guideline-directed therapy improve survival and quality of life.
New research advances canine heart disease care: a breath test could detect heart disease earlier in dogs, and the minimally invasive M-TEER procedure is being adapted from humans to treat mitral regurgitation in dogs.
Alnylam reported Q4 2025 adjusted EPS of $1.25, beating estimates, while revenue of $1.10 billion missed consensus despite 85% growth. Amvuttra sales surged 189% to $826.6 million. The stock fell 4.1% after the mixed results.
Biotech funding roundup: $8M CIRM grant to Siren, $3.5M pre-seed for Claryx, Syntax Bio's $14.4M Series A, €80M Novo Nordisk Foundation programme, and Appili's NIAID contract termination.
Cardiol Therapeutics announced that Phase II MAvERIC results in recurrent pericarditis were accepted for publication in JAHA. The company also provided updates on its Phase III MAVERIC trial, published ARCHER trial results, and CRD-38 development.
New research and guidelines highlight the promise and perils of AI in medicine, from a Dartmouth study showing AI-drafted patient messages can introduce errors, to the Israel Medical Association's new position paper. Regulatory responses vary, with FDA guidance and state laws still evolving.
Semaglutide improves kidney, survival, and quality-of-life outcomes in type 2 diabetes with CKD, per FLOW trial analyses. Benefits were consistent across cardiovascular and severity subgroups, adding eight full-health days per year.
President Trump said Novartis CEO Vas Narasimhan told him the drugmaker is building 11 U.S. plants due to tariff policies. Novartis confirmed progress on facilities in North Carolina, California, and Florida. Narasimhan also said he has no plans to step down as CEO.
Novartis posted Q2 2026 earnings above expectations but a 50% drop in Entresto sales from U.S. generics hurt performance. The company highlighted new EU and Japan approvals for Rhapsido and Itvisma, and a manufacturing restructuring including a German plant closure and investment in radioligand production. A $1.8 billion peptide drug pact with Unnatural Products was also announced.
A clinical study explores whether echocardiography can detect heart amyloid as an early sign of Alzheimer’s, while laboratory research maps a biphasic gene expression cascade in the brain that identifies new therapeutic targets.
Cardiol Therapeutics announced the publication of its Phase II MAvERIC study results in the Journal of the American Heart Association. The study showed CardiolRx led to rapid and sustained reductions in pericarditis pain and inflammation with a favorable safety profile. The findings support the ongoing Phase III MAVERIC trial.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07771231 |
Kosmos PLAX EF Pivotal Study |
ACTIVE_NOT_RECRUITING | |
| NCT07766109 |
Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery |
NOT_YET_RECRUITING | PHASE4 |
| NCT07763353 |
Effects of Slow-paced Breathing on Heart Rate Variability in Patients With Heart Failure |
NOT_YET_RECRUITING | NA |
| NCT07753681 |
Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System |
RECRUITING | |
| NCT07753135 |
Association of Heart Failure Aggravation and Device-based Sensor Parameters |
ACTIVE_NOT_RECRUITING | |
| NCT07752706 |
Breathing Exercises for Dyspnea and Anxiety in Heart Failure |
ACTIVE_NOT_RECRUITING | NA |
| NCT07750262 |
Mobile Health Intervention to Increase Activity in Heart Failure Study |
NOT_YET_RECRUITING | NA |
| NCT07749183 |
A Photoplethysmography-Based Machine Learning Algorithm for Early Atrial Fibrillation Detection: A Prospective Validation Study |
RECRUITING | |
| NCT07743125 |
Patient-Executed, Clinician-Confirmed Diuretic Titration in Pulmonary Artery Pressure-Guided Heart Failure (SURPASS-HF) |
COMPLETED | NA |
| NCT07741305 |
Comparison of Three-dimensional and Two-dimensional Left Ventricle Strain With Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction |
RECRUITING |
