Also known as: HF
Heart failure is a serious clinical syndrome in which the heart cannot pump enough blood and oxygen to meet the body’s needs. It is a chronic condition with episodic decompensation and can cause dyspnea, edema, fatigue, and repeated hospitalizations. Early diagnosis and guideline-directed therapy improve survival and quality of life.
An experimental study found remote ischemic conditioning protected the heart during anthracycline treatment in tumor-bearing mice without reducing antitumor efficacy. The work supports the ongoing RESILIENCE clinical trial in cancer patients.
Phase 1 data in 17 adults with Friedreich's ataxia cardiomyopathy showed AAVrh.10hFXN (LX2006) was generally well tolerated and showed signs of biological activity. The gene therapy is being advanced into a larger trial.
CVRx announced first-patient enrollment in the BENEFIT-HF trial, a 2,500-patient heart failure study across about 150 U.S. and German centers. The trial will evaluate all-cause mortality and heart failure decompensation events through 2032.
Research in the United Kingdom found that preventing type 2 diabetes cut care-related greenhouse gas emissions by about 67%, while well-controlled disease was linked to 21% lower emissions than uncontrolled diabetes.
More cancer survivors are living long enough to face lasting cardiovascular effects of treatment. Cardio-oncology clinics are managing heart failure, valvular disease and radiation-related heart disease.
Compass Therapeutics reported mixed Phase 2/3 data for tovecimig in biliary tract cancer and plans to meet with the FDA for a BLA discussion. The study met its primary ORR endpoint (17% vs 5%), while PFS and OS data are due late this quarter.
Two studies found cardiac MRI-derived biomarkers may improve heart failure risk assessment. Epicardial adipose tissue index was linked to HFpEF risk, while imaging-derived SvO2 predicted hospitalization and death.
Novartis reported 2025 sales of $54.5 billion, up 8%, while earnings per share rose 15% to $8.98. Amarin reported fiscal 2025 revenue of $213.6 million, down 6.5%, and narrowed its net loss per share to $0.09 from $0.20.
A multicenter retrospective cohort study of 17 patients with type 2 diabetes and end-stage renal disease found injectable semaglutide was associated with descriptive changes in glycemic control and body weight. No cardiovascular deaths, nonfatal myocardial infarctions, or nonfatal strokes were observed during follow-up.
A study found seniors with screening-detected atrial fibrillation had a roughly threefold higher risk of heart failure. Heart failure was often diagnosed within six months.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07604727 |
AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation |
NOT_YET_RECRUITING | NA |
| NCT07604467 |
The Role of CD34+ Stem Cells in the Pathogenesis of Takotsubo Syndrome |
RECRUITING | |
| NCT07601867 |
Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Atery Bypass Grafting |
NOT_YET_RECRUITING | |
| NCT07601828 |
Oxygen Delivery Index (ODIN) Study |
NOT_YET_RECRUITING | NA |
| NCT07601724 |
The Impact of Volume Overload on Obstructive Sleep Apnea in Patients With Congestive Heart Failure |
RECRUITING | |
| NCT07601087 |
A Clinical Study of HRS-7156 in Healthy Participants |
NOT_YET_RECRUITING | PHASE1 |
| NCT07597512 |
Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure |
NOT_YET_RECRUITING | |
| NCT07596329 |
Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal |
NOT_YET_RECRUITING | PHASE3 |
| NCT07594886 |
Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF) |
ACTIVE_NOT_RECRUITING | |
| NCT07592494 |
Comparison of the Effects of Different Upper Extremity Aerobic Exercise Training Protocols on Arm Functional Capacity in Patients With Heart Failure With Cardiac Implantable Electronic Devices |
NOT_YET_RECRUITING | NA |
