Mental Health Mission Mood Disorder Cohort Study

Summary

The current study aims to understand why some people with depression respond to treatment and others do not, using markers of clinical symptoms, both clinician reported outcome measures and patient reported outcome measures, demographic information, cognitive function, genetic sequence information (genomic), chemical measures of metabolism (metabolomic), protein makeup (proteomic) and the body's natural defence system (immune/inflammatory markers) together with collections of cells that will facilitate new research to drive improvements in diagnosis and treatment of mood disorders that may be proving difficult to treat. This will allow future clinical trials within the NHS, academia and industry to drive forward new approaches and treatments.

Participants who provide consent for re-contact for future treatment trials and other research studies have the potential to benefit from this with participation in experimental studies and clinical trials associated with improved patient outcomes. Overall, the cohort will generally support greater access to research opportunities for a wider population of people.

Conditions

• Depression - Major Depressive Disorder
• Depression Bipolar
• Treatment Resistant Depression

Sponsors & Collaborators

• Newcastle University

  collaborator OTHER

• University of Nottingham

  collaborator OTHER

• University of Exeter

  collaborator OTHER

• University of Southampton

  collaborator OTHER

• University of Birmingham

  collaborator OTHER

• University of Manchester

  collaborator OTHER

• University of Liverpool

  collaborator OTHER

• Avon and Wiltshire Mental Health Partnership NHS Trust

  collaborator OTHER_GOV

• Cambridgeshire and Peterborough NHS Foundation Trust

  collaborator OTHER

• University of Cambridge

  collaborator OTHER

• Cardiff University

  collaborator OTHER

• Cardiff and Vale University Health Board

  collaborator OTHER_GOV

• University of Edinburgh

  collaborator OTHER

• University of Glasgow

  collaborator OTHER

• University College, London

  collaborator OTHER

• Sheffield Health and Social Care NHS Foundation Trust

  collaborator UNKNOWN

• King's College London

  collaborator OTHER

• Imperial College London

  collaborator OTHER

• Oxford Health NHS FT

  collaborator UNKNOWN

• Cumbria, Northumberland, Tyne and Wear NHS FT

  collaborator UNKNOWN

• South London and Maudsley NHS FT

  collaborator UNKNOWN

• Nottinghamshire Healthcare NHS FT

  collaborator UNKNOWN

• Devon Partnership Trust

  collaborator UNKNOWN

• Hampshire and Isle of Wight Health NHS FT

  collaborator UNKNOWN

• Birmingham and Solihull Mental Health NHS Trust

  collaborator UNKNOWN

• Mersey Care NHS FT

  collaborator UNKNOWN

• NHS Lothian

  collaborator OTHER_GOV

• NHS Greater Glasgow & Clyde

  collaborator UNKNOWN

• Camden & Islington NHS FT

  collaborator UNKNOWN

• West London NHS FT

  collaborator UNKNOWN

• Central and North West London NHS FT

  collaborator UNKNOWN

• University of Oxford

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-10-01

Primary Completion

2028-01-31

Completion

2028-01-31

Countries

• United Kingdom

Study Locations