Also known as: non-fatal stroke, nonfatal stroke
Stroke occurs when blood flow to part of the brain is blocked or when a cerebral blood vessel ruptures, causing brain injury due to ischemia or hemorrhage. It is a major cause of death and long-term disability.
A retrospective cohort study of 14,118 matched pairs found tirzepatide associated with lower risks of stroke and death than other GLP-1 receptor agonists in patients with atrial fibrillation and type 2 diabetes. Absolute differences were 2.1 percentage points for stroke and 6.2 for mortality at one year. Randomized trials are needed before recommendations change.
A CREST-2 substudy presented at ISC 2026 found that revascularization did not improve cognitive outcomes in patients with asymptomatic carotid artery disease. Cognitive decline occurred only in patients who experienced a stroke, with no differences between revascularization and medical therapy alone.
Orforglipron beat oral semaglutide on blood sugar and weight in type 2 diabetes, with higher discontinuation rates. GLP-1 hair loss is typically temporary telogen effluvium.
Adjunct intra-arterial alteplase after thrombectomy improved 90-day functional recovery in LVO stroke (57.5% vs 42.5%). Headache occurs in 46% of hemorrhagic stroke patients; only 21.8% of stroke/TBI patients receive inpatient rehab.
Eli Lilly will file its triple-agonist obesity drug retatrutide in early 2027 via a Biologics License Application, seeking stronger market protections. Positive Phase 3 results showed up to 22.6% weight loss, while cardiovascular safety data raised some questions.
A Cochrane review finds exercise for hip osteoarthritis reduces pain by 7 points on a 100-point scale, below the 12-point threshold for noticeable benefit. A survey shows 76% of physical therapy patients skip home exercises, citing forgetfulness and time constraints. A study reports only 22% of stroke and brain injury survivors receive intensive inpatient rehab, with disparities by race, insurance, and income.
First-line pulsed field ablation achieved 56% vs 30% success with drugs in persistent AFib (HR 0.46). Device-related serious adverse events occurred in 5.1%. Results published in NEJM.
A study finds that white matter disease detected on CT scans signals a higher risk for stroke or dementia compared to MRI-only findings. CT-detected WMD may represent more advanced cerebrovascular injury, highlighting the need for modality-specific interpretation of incidentally discovered brain abnormalities.
Hematologic cancer survivors face elevated CVD risk and fourfold higher heart failure risk. Cardiac screening is low among cardiotoxic treatment recipients. A trial found simple risk assessment may suffice.
XBiotech Inc. (NASDAQ: XBIT) is a clinical-stage biopharmaceutical company specializing in True Human monoclonal antibodies. Pipeline candidates include Natrunix and Hutrukin. The company is held by small-cap value ETFs.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07779928 |
An Innovative Proprioceptive Instrument for Upper Extremities |
NOT_YET_RECRUITING | |
| NCT07778771 |
CEEEC-II: A 12-Week Physical and Cognitive Enrichment Extension Study in Older Stroke Survivors With Multimorbidity |
NOT_YET_RECRUITING | NA |
| NCT07778342 |
tACS and Upper Limb Rehabilitation in Chronic Stroke |
NOT_YET_RECRUITING | NA |
| NCT07776392 |
Occupational Therapy Instructmental Activities of Daily Living and Psychosocial Modules Program for Stroke Survivors |
COMPLETED | NA |
| NCT07773038 |
Digital Health Literacy and Social Participation in Individuals With Hemiplegia |
NOT_YET_RECRUITING | |
| NCT07772947 |
Effects of Hyperbaric Oxygen Combined With Aerobic Exercise on Working Memory Among Stroke Patients |
COMPLETED | NA |
| NCT07772323 |
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury |
NOT_YET_RECRUITING | |
| NCT07772284 |
Repetitive Action Simulation Circuit Training to Reduce Arm Weakness After a Stroke |
COMPLETED | NA |
| NCT07770776 |
Short Term Effects of Early Respiratory Muscle Training on Respiratory Muscle Strength in Inpatient Acute Stroke |
ACTIVE_NOT_RECRUITING | NA |
| NCT07769294 |
PLasmatic Extracellular Vesicles AS Biomarkers of nEural Tissue Damage |
NOT_YET_RECRUITING |
