Atrial fibrillation is a common heart rhythm disorder in which the upper chambers of the heart beat irregularly and often rapidly. It can reduce the heart's pumping efficiency and raise the risk of stroke and other complications.
The International Cardio-Oncology Society has released new guidelines for managing cancer therapy-related cardiac dysfunction, addressing educational gaps identified in a survey of 220 healthcare providers. The survey found highest educational needs for topics like immune checkpoint inhibitor-associated myocarditis and atrial fibrillation management.
The U.S. cardiovascular drugs market is projected to reach $37.03 billion by 2035, growing at a CAGR of 2.68%. Europe's anticoagulants market is expected to reach $23.68 billion by 2033, expanding at a CAGR of 8.22%.
Experts discuss balancing efficacy and safety in BTK inhibitor plus venetoclax combination therapy for CLL, including BTK lead-in strategies to reduce tumor lysis syndrome risk and the benefits of all-oral fixed-duration regimens.
Medtronic reported interim Affera Sphere-9 data showing 65.5% of VT patients were free from recurrence at six months. The FDA granted Breakthrough Device designation for Sphere-9 and approved a U.S. pivotal IDE.
A study found seniors with screening-detected atrial fibrillation had a roughly threefold higher risk of heart failure. Heart failure was often diagnosed within six months.
Wearable technologies are transforming clinical trials and healthcare with continuous monitoring capabilities, though clinical validation remains limited. While ECG features provide useful data for cardiac monitoring, many wearable metrics lack clinical accuracy and can cause patient anxiety. The technology shows promise for activity tracking and specific medical applications but requires cautious interpretation.
CRISPR Therapeutics reported a Q4 2025 loss of $1.37 per share, missing estimates, with revenues of $0.9 million falling short of expectations. The company's partner Vertex recorded $54 million in Casgevy sales for the quarter, with regulatory submissions for pediatric label expansion planned for early 2026.
New research shows patients on GLP-1 drugs may need to delay endoscopy procedures due to retained gastric contents, while a Cleveland Clinic study found 45% of obesity patients maintained weight loss one year after stopping the medications.
The phase 3 OCEANIC-STROKE trial of 12,327 patients showed asundexian, an oral Factor XIa inhibitor, reduced ischemic stroke recurrence by 26% when added to standard antiplatelet therapy, with no increase in major bleeding events.
Bristol Myers Squibb's growth portfolio increased 17% in 2025, partially offsetting a 15% decline in legacy products facing generic competition. The company's stock gained 11.4% in the past month on strong fourth-quarter results.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07614659 |
Uppsala Self-Screening of Cardiovascular Health (U-SCREEN) |
RECRUITING | NA |
| NCT07580937 |
Studying Heart Ablation After Left Atrial Closure in High-Bleeding-Risk Atrial Fibrillation Patients |
COMPLETED | |
| NCT07575867 |
CLOT-LESS - CLOsure Tailored: LEss Antithrombotic Strategy After LAAC for Stroke Prevention |
RECRUITING | |
| NCT07572253 |
A Study of Using CARTO SOUND™ FAM to Guide Pulsed Field Ablation for Atrial Fibrillation |
NOT_YET_RECRUITING | NA |
| NCT07570940 |
A Study Of Stellate Ganglion Blockade With Liposomal Bupivacaine In Preventing Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting Surgery |
NOT_YET_RECRUITING | PHASE4 |
| NCT07569016 |
BIS-Guided Sedation Versus Standard Clinical Sedation During Elective Electrical Cardioversion for Atrial Fibrillation |
RECRUITING | NA |
| NCT07565337 |
The Application of Biomarkers in the Care of Patients With Atrial Fibrillation |
WITHDRAWN | |
| NCT07560644 |
Restoring Sinus Rhythm Using Dual-Shock Technique in Patients With Atrial Fibrillation |
NOT_YET_RECRUITING | PHASE2/PHASE3 |
| NCT07551947 |
Insulin Resistance as a Predictor of Pulsed Field Ablation Success in Atrial Fibrillation (HOMA-PULSE) |
ENROLLING_BY_INVITATION | |
| NCT07540065 |
AI-Assisted Workflow for Occult Atrial Fibrillation Detection After Ischemic Stroke: A Prospective Randomized Trial |
NOT_YET_RECRUITING | NA |
