A study of over 600,000 patients reveals GLP-1 drugs may reduce addiction across multiple substances, with 50% fewer substance-related deaths and significant reductions in overdoses and hospitalizations. The drugs work by dampening dopamine signaling in brain reward centers. Researchers are exploring broader applications for these medications beyond diabetes and obesity treatment.
New studies show SGLT2 inhibitors and GLP-1 receptor agonists reduce risks of kidney failure, cardiovascular events, and liver complications in patients with type 2 diabetes, with particularly strong benefits in those with cirrhosis.
UK and Brazil issue warnings about possible pancreatitis link to GLP-1 weight-loss drugs, while WADA monitors their use in Olympic athletes amid concerns about muscle loss and performance effects.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07471542 |
Copper Supplementation in Cirrhosis |
RECRUITING | NA |
| NCT07270809 |
To Study the Clinical Course and Outcomes of Non-electively Hospitalised Patients of Chronic Liver Disease (CLD) With Hepatic or Extra-hepatic Predominant Organ Failure(s) at 6 Months. |
NOT_YET_RECRUITING | |
| NCT07191886 |
Measuring Patient Reported Needs in Outpatient Liver Disease Management |
RECRUITING | |
| NCT06909175 |
Comparing Portal Vein Assessment by Intraoperative Doppler and Transesophageal Echocardiography |
COMPLETED | |
| NCT06797011 |
Efficacy of Plasmapheresis in Patients of Drug-Induced Liver Injury (DILI) With Underlying Chronic Liver Disease |
NOT_YET_RECRUITING | PHASE2/PHASE3 |
| NCT06743464 |
Effect of Perioperative Oral Rifaximin on Early Graft Dysfunction in Adult Living Donor Liver Transplant |
RECRUITING | NA |
| NCT06656767 |
Somatic Mutation in Chronic Liver Disease |
ENROLLING_BY_INVITATION | |
| NCT06642740 |
Study on the Efficacy and Safety of Avatricopal in Patients With CLD Complicated With Thrombocytopenia |
ENROLLING_BY_INVITATION | |
| NCT06592820 |
Endoscopic Ultrasound Shear Wave Elastography Study |
RECRUITING | |
| NCT06587568 |
Mobile Chat Messaging for Alcohol Reduction in Patients With Chronic Liver Diseases |
ACTIVE_NOT_RECRUITING | NA |
