Effect of Physical Form of Apples on Gastrointestinal Function and Satiety: a MRI Study

Summary

Different physical form of apples had a significant effect on satiety and blood sugar levels which was shown in a 1977 study by Haber and his team (Haber et al.1977).It was suggested that , this effect was due to processing of the apples which modified the bioavailability of carbohydrate and fiber content.However this was not enough to explain the mechanistic effect of the apples. Within the last decade, the role of magenetic resonance imaging has been very promising in understanding gastrointestinal function and physiology. Recent MRI studies have measured changes in gastrointestinal volumes due to the effect of fermentable carbohydrates.

Apple contains fermentable carbohydrates or FODMAPs. They are known to be poorly absorbed in the small and exert an osmotic effect by increasing markedly small bowel water content in the intestinal lumen as demonstrated in imaging studies.(Murray et al 2014 and Placidi et al 2012). A reduction of FODMAPs in the diet of IBS sufferers has been found to alleviate functional gut symptoms demonstrated in several randomised controlled trials.

In order to fully understand the 1977 Haber study, the investigators would like to repeat the study using modern MRI methods in healthy volunteers and measure the volume changes in the stomach, small bowel and colon. In addition appetite and symptoms would also be investigated after ingesting each test meal.

Conditions

• Gastrointestinal Symptoms

Interventions

OTHER

Whole apples

350 of whole apples containing 49g of available carbohydrate with 173ml water

OTHER

Apple puree

384g of apple puree containing 44g of available carbohydrates with 224 ml water

OTHER

Apple Juice

338g apple juice containing 46g of available carbohydrate with 260 ml water

Sponsors & Collaborators

• King's College London

  collaborator OTHER

• University of Nottingham

  lead OTHER

Principal Investigators

• Robin Spiller, MD,FRCP · University of Nottingham

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-02-29

Primary Completion

2016-08-31

Completion

2016-08-31

Countries

• United Kingdom

Study Locations