A first-in-human T-cell therapy showed lasting benefit in children with DIPG and relapsed CNS tumors, while a preclinical mRNA vaccine reduced neuroblastoma tumor size by 70%. Aneuploidy predicted response to olaparib plus irinotecan.
FDA approved a subcutaneous starting dose of Leqembi for early Alzheimer's disease. AAIC 2026 real-world data showed most patients stable or improved; a mouse study found KCL-286 repaired DNA damage and reduced inflammation.
New research challenges the theory that ketamine's psychedelic effects drive its therapeutic benefits for alcohol use disorder. A study of 96 participants found no link between ketamine's psychoactive experiences and improved abstinence rates. The findings suggest other mechanisms, such as brain network alterations, may explain ketamine's effectiveness in treating addiction.
The Pathways clinical trial into puberty blockers has been paused after the MHRA raised concerns about minimum age limits and unquantified long-term biological risks, with recruitment now suspended pending resolution.
The MHRA has raised new safety concerns about the PATHWAYS clinical trial investigating puberty blockers in young people with gender incongruence, pausing preliminary work until issues are resolved with sponsor King's College London.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07779174 |
Prevalence and Measurement of Delayed Gastric Emptying in Patients Receiving Extracorporeal Membrane Oxygenation |
NOT_YET_RECRUITING | |
| NCT07771426 |
The SPARK-PMDD Study |
NOT_YET_RECRUITING | |
| NCT07768865 |
Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease |
RECRUITING | |
| NCT07767058 |
Mindfulness for Central Serous Chorioretinopathy |
NOT_YET_RECRUITING | NA |
| NCT07762807 |
Colchicine And Dialysis Patients; a Feasibility Study |
RECRUITING | NA |
| NCT07757646 |
A Group Intervention for Parents of Autistic Young People With Anorexia Nervosa: An Exploration of How Parents Make Sense of and Integrate Concepts From the Group Into Family Life |
ACTIVE_NOT_RECRUITING | |
| NCT07726693 |
Apixaban to Prevent Decompensation of Early Liver Cirrhosis Trial |
NOT_YET_RECRUITING | PHASE3 |
| NCT07704294 |
Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool |
NOT_YET_RECRUITING | |
| NCT07688837 |
Foot Care in Care Homes |
NOT_YET_RECRUITING | |
| NCT07671664 |
Triage Radiology Imaging Assessment for Greater Effectiveness |
NOT_YET_RECRUITING | NA |
