MedTrace Logo

Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma

NCT03612700 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2018-10-17

No results posted yet for this study

Summary

Fatty acids containing a cyclopropane ring in their structure (CPFA) have been found in plants, fungi, a wide variety of bacteria and recently detected in dairy products and bovine meat. Little is known about CPFA in mammals, especially in human tissues. This work aims at investigating the presence of CPFA in plasma of humans after a regular consumption of CPFA from milk and cheese. A free living diet controlled in CPFA, mainly deriving from Grana Padano cheese and whole milk containing CPFA, will be consumed by 10 healthy normal weight volunteers for three weeks, after one week of dairy products and bovine meat restricted diet. Plasma of volunteers will be collected at 8 different timepoints for lipid extraction, CPFA identification and quantification by GC-MS. A preliminary pilot in vivo acute study (involving only 1 subject) will be performed for investigating the post-prandial response curve of CPFA after a portion of Grana Padano cheese.

Conditions

  • Biological Availability

Interventions

OTHER

CPFA-rich foods

Daily consumption of Grana Padano cheese (50 g) and whole milk (250 mL) for 3 weeks.

Sponsors & Collaborators

  • University of Parma

    lead OTHER

Principal Investigators

  • Daniele Del Rio, Professor · Department of Food and Drugs

  • Augusta Caligiani, Professor · Department of Food and Drugs

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-08-06
Primary Completion
2018-09-28
Completion
2018-09-28

Countries

  • Italy

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03612700 on ClinicalTrials.gov