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The Role of Visfatin in Obesity and Periodontal Disease

NCT03470987 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2018-03-21

No results posted yet for this study

Summary

Visfatin is an adipokine that plays an important role in immune functions as a growth factor, enzyme, and proinflammatory mediator. The investigators aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP). Patients were categorized as obese (O) (n=31) or non-obese (nO) (n=19). Groups were divided into four subgroups according to periodontal conditions: (1) periodontally healthy without obesity (nO-Ctrl); (2) GCP without obesity (nO-CP); (3) periodontally healthy with obesity (O-Ctrl); and (4) GCP with obesity (O-CP). Demographic variables and anthropometric and laboratory data were recorded. Periodontal measurements were recorded at baseline and 3rd months after either non-surgical periodontal treatment or calorie restricted diet therapy. At the same time GCF samples were taken from patients to analyze TNF-alpha, IL-6, and visfatin levels.

Conditions

Interventions

PROCEDURE

Phase I Periodontal therapy

Oral hygiene instuction, scaling and root planning

DIETARY_SUPPLEMENT

Metabolic control

Calorie restricted diet

Sponsors & Collaborators

  • Gazi University

    lead OTHER

Principal Investigators

  • Deniz Cetiner, Prof · Gazi University Faculty of Dentistry Department of Periodontology

Eligibility

Min Age
20 Years
Max Age
68 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-10-31
Primary Completion
2014-09-30
Completion
2014-09-30

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03470987 on ClinicalTrials.gov