MedTrace Logo

TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases

NCT03558906 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 87

Last updated 2018-06-15

No results posted yet for this study

Summary

This study aimed to investigate gingival crevicular fluid (GCF) and salivary hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) levels in different periodontal diseases. A total of 87 individuals, 20 patients with generalized aggressive periodontitis, 20 with chronic periodontitis, 26 with gingivitis and 21 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index and plaque index were recorded. GCF and salivary HIF-1α, VEGF and TNF-α levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.

Conditions

  • Periodontal Diseases

Sponsors & Collaborators

  • Celal Bayar University

    collaborator OTHER

  • Ege University

    collaborator OTHER

  • Aydin Adnan Menderes University

    lead OTHER

Eligibility

Min Age
27 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-01
Primary Completion
2016-03-02
Completion
2016-12-26

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03558906 on ClinicalTrials.gov