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Effect of Nonsurgical Periodontal Treatment on Apelin and Oxidative Stress Levels

NCT06850987 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2025-07-30

No results posted yet for this study

Summary

Periodontitis is a multifactorial, chronic inflammatory disease triggered by microorganisms in the dental biofilm. The limited data of clinical periodontal measurements in the diagnosis of periodontitis have led to the search for more reliable biomarkers that can be used in the diagnosis and follow-up of periodontal diseases. Apelin is another adipokine that has been investigated in a small number of studies so far; its receptor (apelin reseptor (APJ)) was first identified in 1993 and later isolated as a molecule in 1998. Studies have focused on this form of apelin-13 due to its high biological activity. Although apelin-13 is considered the most biologically active form, it has been shown that apelin-36 has a much higher binding affinity to APJ than apelin-13. Periodontitis is the most common cause of tooth loss in adults, and is associated with systemic conditions such as metabolic syndrome, diabetes mellitus, and cardiovascular disease. The elucidation of these possible interactions has been the focus of many studies. Apelin is associated with insulin secretion, as well as its effects on lipid and glucose metabolism. Studies in both humans and animals have shown that type 2 diabetes and obesity are typically associated with increased plasma apelin levels. Based on this observation, recent studies have shown that salivary and serum apelin levels are higher in individuals with chronic periodontitis and type 2 diabetes compared to healthy individuals. Considering all this information, the investigators considered that apelin may be a biomarker for periodontal diseases due to its inflammation-regulating effects as a result of the change in gingival crevicular fluid (GCF) apelin-13, apelin-36 and total oxidant status (TOS)/total antioxidant status (TAS) levels compared to the initial level after non-surgical periodontal treatment in systemically healthy and periodontitis individuals, considering the relationship of adipokines with periodontal disease in this study.

Conditions

  • Periodontitis

Interventions

PROCEDURE

non surgical periodontal therapy

All participants will have their non-surgical periodontal treatments completed after samples are taken and periodontal measurements are taken at the beginning.

OTHER

measurement of periodontal clinical parameters

Periodontal measurements will be taken from all participants at baseline, 1 month, 3 months and 6 months

OTHER

Gingival crevicular fluid samples will be collected

Gingival crevicular fluid samples will be collected from all participants at baseline, 1 month, 3 months and 6 months

Sponsors & Collaborators

  • Recep Tayyip Erdogan University Training and Research Hospital

    collaborator OTHER

  • Hatice Yemenoğlu

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-16
Primary Completion
2025-05-14
Completion
2025-06-14

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06850987 on ClinicalTrials.gov